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KMID : 0861020170320060023
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Korea Journal of Herbology
2017 Volume.32 No. 6 p.23 ~ p.29
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Hyperuricemic effects of Alpiniae Oxyphyllae Fructus extracts
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Lee Young-Sil
Kim Ji-Youn
Kim Seung-Hyung
Kim Dong-Seon
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Abstract
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Objective : Hyperuricemia is a metabolic disease characterized by elevated blood uric acid levels, and its prevalence is rapidly increasing worldwide. Alpiniae Oxyphyllae Fructus (AO) belonging to Zingiberaceae is one of well-known traditional medicines in China and Korea, and has been used to treat intestinal disorders, urosis, diuresis, and chronic glomerulonephritis traditionally. However, the effect of AO has not been studied. In this study we investigated the anti-hyperuricemic effect of AO, and the mechanisms underlying the effect in potassium oxonate (PO)-induced hyperuricemic rats.
Methods : To examine the anti-hyperuricemic effects of the AO extract, serum uric acid levels were analyzed in normal and PO-induced hyperuricemic rats. The mechanism underlying the effects of the AO extract on uric acid levels was studied through xanthine oxidase (XOD) activity test and uric acid uptake assay in vitro . The chemical finger printing of the AO extract was analyzed using HPLC-DAD.
Results : The AO extract significantly reduced serum uric acid levels in normal as well as PO-induced hyperuricemic rats. It also significantly inhibited the uptake of uric acid in oocytyes and human embryonic kidney cells (HEK293) expressing urate transporter (URAT)1, but not XOD activity in vitro . The chemical finger printing analysis of the AO extract showed nootkatone as a main component.
Conclusion : The AO extract exhibits anti-hyperuricemic effects, and these effect were accompanied by increasing excretion of uric acid in kidney. Therefore, the AO extract could be used for prevention or treatment of hyperuicemia and gout.
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KEYWORD
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Alpiniae Oxyphyllae Fructus, Hyperuricemia, Xanthine oxidase, Urate transporter
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